GENERIC Identity: prednisoneBRAND NAME: Deltasone, Orasone, Prednicen-M, Liquid PredDRUG CLASS Along with MECHANISM: Prednisone is an oral, artificial (man-made) corticosteroid used for suppressing the disease fighting capability and inflammation. It has benefits similar to other corticosteroids for example triamcinolone (Kenacort), methylprednisolone (Medrol), prednisolone (Prelone) and dexamethasone (Decadron). These synthetic corticosteroids mimic the action of cortisol (hydrocortisone), the naturally-occurring corticosteroid stated in the body by the adrenal glands. Adrenal cortical steroids have many effects on the body, but they also most often are used for their effective anti-inflammatory effects, particularly in those ailments in which the immune system plays an important role. Such conditions include joint inflammation, colitis, asthma, bronchitis, certain pores and skin rashes, and allergic and also inflammatory conditions of the nose and eyes. Prednisone is lazy in the body and, in order to be powerful, first must be converted to prednisolone through enzymes in the liver. Thus, prednisone may not work as effectively around people with liver disease in whose ability to convert prednisone to prednisolone is usually impaired
PRESCRIPTION: yesGENERIC AVAILABLE: yesPREPARATIONS: Pills of 2.5, 5, 15, 20, and 50 milligrams. Oral solution or syrup with 5mg/5mlSTORAGE: Store at room temps 20-25°C (68-77°F), and keep away from moisture.Recommended FOR: Prednisone is used in the treating inflammatory conditions or disorders in which the immune system plays a crucial role. Since prednisone is used in a great number of conditions, only the most common or even established uses are mentioned here. Prednisone most often is used for treating several types of arthritis, ulcerative colitis, Crohn’s disease, systemic lupus, allergic reactions, asthma and critical psoriasis. It also is used for getting rid of leukemias, lymphomas, idiopathic thrombocytopenic purpura and autoimmune hemolytic anemia. Corticosteroids, including prednisone, are commonly used to suppress the disease fighting capability and prevent the body from rejecting transplanted bodily organs. Prednisone is used as replacement remedy in patients whose adrenal glands are unable to produce sufficient variety of cortisol.DOSING: The initial dose of prednisone can vary depending on the condition being treated along with the age of the patient. The starting up dose may be from 5 to 60 mg daily and often is adjusted based on the response of the condition receiving treatment. Corticosteroids typically do not make immediate effects and must be utilized for several days before maximal effects are seen. It may take much longer before conditions respond to treatment. Continuous therapy with prednisone causes the adrenals to atrophy and stop producing cortisol. When prednisone is discontinued after a period of prolonged therapy, this dose of prednisone must be tapered (low gradually) to allow the adrenal glands the perfect time to recover. (See side effects.) It is recommended that prednisone be taken with food. Pharmaceutical INTERACTIONS: Prednisone may interact with estrogens plus phenytoin (Dilantin). Estrogens may reduce the action of enzymes in the liver which break down (eliminate) the productive form of prednisone, prednisolone. As a result, the levels with prednisolone in the body may increase along with lead to more frequent unwanted effects. Phenytoin increases the activity of digestive enzymes in the liver that wear out (eliminate) prednisone and thereby may perhaps reduce the effectiveness of prednisone. Therefore, if phenytoin is being taken, a higher dose of prednisone may be required.
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